Coexpression of MAGE-A peptides and HLA class I molecules in hepatocellular carcinoma.

@article{Roch2010CoexpressionOM,
  title={Coexpression of MAGE-A peptides and HLA class I molecules in hepatocellular carcinoma.},
  author={Nadine Roch and Asad Kutup and Yogesh Kumar Vashist and Emre F. Yekebas and Viktor Kalinin and Jakob Robert Izbicki},
  journal={Anticancer research},
  year={2010},
  volume={30 5},
  pages={1617-23}
}
Melanoma antigen (MAGE)-A derived peptides are tumour-specific and induce a strong in vitro T-cell response, if presented with human leukocyte antigen (HLA) molecules, which are involved in T-cell-mediated immune surveillance. MAGE-A-derived peptides are recognised by autologous cytotoxic T lymphocytes. The MAGE-A expression profile of hepatocellular carcinomas (HCC) was analysed by PCR assay covering MAGE-A transcripts in 13 patients. MAGE-A peptide expression was determined using a reverse… CONTINUE READING