Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma.

@article{Ochkur2007CoexpressionOI,
  title={Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma.},
  author={Sergei I. Ochkur and Elizabeth A. Jacobsen and Cheryl A. Protheroe and Travis L. Biechele and Ralph S. Pero and Michael P. McGarry and Hui-ying Wang and Katie O'neill and Dana C. Colbert and Thomas Vail Colby and Huahao H Shen and Michael R. Blackburn and Charles C. Irvin and James Joseph Lee and Nancy A. Lee},
  journal={Journal of immunology},
  year={2007},
  volume={178 12},
  pages={7879-89}
}
Mouse models of allergen provocation and/or transgenic gene expression have provided significant insights regarding the cellular, molecular, and immune responses linked to the pathologies occurring as a result of allergic respiratory inflammation. Nonetheless, the inability to replicate the eosinophil activities occurring in patients with asthma has limited their usefulness to understand the larger role(s) of eosinophils in disease pathologies. These limitations have led us to develop an… CONTINUE READING