Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils

@article{Lorant1991CoexpressionOG,
  title={Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils},
  author={Diane E. Lorant and Kamala D. Patel and Thomas M McIntyre and Rodger P McEver and Stephen M. Prescott and Guy A. Zimmerman},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={115},
  pages={223 - 234}
}
The adhesion of polymorphonuclear leukocytes (PMNs) to vascular endothelial cells (EC) is an early and fundamental event in acute inflammation. This process requires the regulated expression of molecules on both the EC and PMN. EC stimulated with histamine or thrombin coexpress two proadhesive molecules within minutes: granule membrane protein 140 (GMP-140), a member of the selectin family, and platelet-activating factor (PAF), a biologically active phospholipid. Coexpression of GMP-140 and PAF… CONTINUE READING