Coexpressed Auxiliary Subunits Exhibit Distinct Modulatory Profiles on AMPA Receptor Function

  title={Coexpressed Auxiliary Subunits Exhibit Distinct Modulatory Profiles on AMPA Receptor Function},
  author={Konstantin V. Khodosevich and Eric Jacobi and Paul Farrow and Anton Schulmann and Alexandru Rusu and Ling Ling Zhang and Rolf Sprengel and Hannah Monyer and Jakob von Engelhardt},
Gating properties and surface trafficking of AMPA receptors (AMPARs) are modulated by auxiliary subunits. Here we studied the function of coexpressed auxiliary subunits belonging to two different classes. We focused on TARP γ-8 and CKAMP44 in dentate gyrus (DG) granule cells, since both subunits are highly expressed in this cell type. TARP γ-8 and CKAMP44 decrease the rate of deactivation but have an opposing influence on receptor desensitization, which accounts for their differential… CONTINUE READING
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AMPA receptor/TARP stoichiometry visualized by single-molecule subunit counting.

Proceedings of the National Academy of Sciences of the United States of America • 2013
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