Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta.

@article{Passerini2004CoexistingPA,
  title={Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta.},
  author={A. G. Passerini and Denise C. Polacek and Congzhu Shi and Nadeene M. Francesco and Elisabetta Manduchi and Gregory R. Grant and William F. Pritchard and Steven K Powell and Gary Chang and Christian J. Stoeckert and Peter Francis Davies},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 8},
  pages={2482-7}
}
In the arterial circulation, regions of disturbed flow (DF), which are characterized by flow separation and transient vortices, are susceptible to atherogenesis, whereas regions of undisturbed laminar flow (UF) appear protected. Coordinated regulation of gene expression by endothelial cells (EC) may result in differing regional phenotypes that either favor or inhibit atherogenesis. Linearly amplified RNA from freshly isolated EC of DF (inner aortic arch) and UF (descending thoracic aorta… CONTINUE READING