Coexistence of tics and parkinsonism: evidence for non-dopaminergic mechanisms in tic pathogenesis.

@article{Kumar1997CoexistenceOT,
  title={Coexistence of tics and parkinsonism: evidence for non-dopaminergic mechanisms in tic pathogenesis.},
  author={Rahut Amit Kumar and Anthony E Lang},
  journal={Neurology},
  year={1997},
  volume={49 6},
  pages={
          1699-701
        }
}
We report four patients with tics since childhood who presented with typical Parkinson's disease (PD). No alteration in tics occurred before or during the development of symptoms. L-Dopa/carbidopa therapy in three patients improved parkinsonism without worsening tics over 3 months to 11 years of follow-up. Our experience fails to support hypotheses exclusively emphasizing overactivity of dopaminergic function underlying tics that would predict that PD would reduce and L-dopa exacerbate tics… CONTINUE READING