Coexistence of inversion 16 and the Philadelphia chromosome comprising P190 BCR/ABL in chronic myeloid leukemia blast crisis.

@article{Ninomiya2011CoexistenceOI,
  title={Coexistence of inversion 16 and the Philadelphia chromosome comprising P190 BCR/ABL in chronic myeloid leukemia blast crisis.},
  author={Soranobu Ninomiya and Nobuhiro Kanemura and Hisashi Tsurumi and Senji Kasahara and Takeshi Hara and Toshiki Yamada and Hisataka Moriwaki},
  journal={International journal of hematology},
  year={2011},
  volume={93 6},
  pages={806-810}
}
A 63-year-old woman presented with leukocytosis (278 × 10(9)/L) with 72% blasts. Bone marrow blast cells showed cytogenetic abnormality with 46,XX, t(9;22), inv(16). Despite achievement of hematological remission by induction chemotherapy, Philadelphia chromosome did not disappear; chronic myeloid leukemia (CML) in blast crisis (BC) was thus diagnosed. The P190 BCR/ABL fusion transcript was detected. Imatinib mesylate introduced a hematological remission of short duration; however, infiltration… CONTINUE READING