Coexistence of carriers for dopamine and GABA uptake on a same nerve terminal in the rat brain

@article{Bonanno1987CoexistenceOC,
  title={Coexistence of carriers for dopamine and GABA uptake on a same nerve terminal in the rat brain},
  author={Giambattista Bonanno and Maurizio Raiteri},
  journal={British Journal of Pharmacology},
  year={1987},
  volume={91}
}
1 The ability of γ‐aminobutyric acid (GABA) to affect the release of [3H]‐dopamine in rat brain synaptosomes prepared from corpus striatum, frontal cortex and hypothalamus and prelabelled with the radioactive catecholamine in the presence of desipramine was examined. 2 GABA (10–300 μm) increased in a concentration‐dependent way the basal release of [3H]‐dopamine from striatum and cortical synaptosomes; however, its effect was much less pronounced in hypothalamic nerve terminals. 2,4… 
γ‐Aminobutyric Acid and Glycine Modulate Each Other's Release Through Heterocarriers Sited on the Releasing Axon Terminals of Rat CNS
TLDR
It is suggested that transporters specific for GABA or Gly are colocalized on the same nerve terminal in rat spinal cord, cerebellum, and cerebral cortex, but not in hippocampus, which is compatible with the reported coexistence of GABA and Gly in spinal and cerebellar neurons.
Presynaptic Mechanisms Underlying the γ‐Aminobutyric Acid‐Evoked Receptor‐Independent Release of [3H]Norepinephrine in Rat Hippocampus
TLDR
The hypothesis that GABA provoked [3H]NE release by a novel mechanism which involves penetration into the noradrenergic nerve terminals through a GABA carrier located on the NE terminals themselves is supported.
Glutamic Acid and γ‐Aminobutyric Acid Modulate Each Other's Release Through Heterocarriers Sited on the Axon Terminals of Rat Brain
TLDR
It is proposed that high‐affinity GABA or Glu heterocarriers are sited respectively on glutamatergic or GA‐ BAergic nerve terminals in rat cerebral cortex and hippocampus, in keeping with the reported colocalization of GABA and Glu in some cortical and hippocampal neurons.
A novel type of GABA receptor in rat spinal cord?
TLDR
It is concluded that the release of GABA in rat spinal cord may be modulated by an autoreceptor which does not belong to the known GABA receptor subtypes.
Release‐regulating autoreceptors of the GABAB‐type in human cerebral cortex
TLDR
It is concluded that GABA autoreceptors regulating the release of both newly taken up and endogenous GABA are present in human brain and appear to belong to the GABAB subtype.
In vivo release of dopamine from rat striatum, substantia nigra and prefrontal cortex: differential modulation by baclofen
TLDR
The results suggest that GABAB receptors modulate the release of dopamine in the SN and PFC, but do not affect the striatal release of serotonin, which indicates that the role of GABA receptor activation is different in the dopaminergic terminals of the ST and P FC.
Adenosine and Glutamate Modulate Each Other's Release from Rat Hippocampal Synaptosomes
TLDR
The results suggest that, at least in synaptosomal preparations from rat hippocampus, adenosine and glutamate modulate each other's release, and the exact mechanism of such interplay could help in the understanding of excitatory amino acid neurotoxicity.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Presence of a gamma-aminobutyric acid (GABA) uptake system on cholinergic terminals of rat hippocampus: evidence for neuronal coexistence of acetylcholine and GABA?
  • G. Bonanno, M. Raiteri
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1987
TLDR
The results indicate that a GABA transport system is present on cholinergic terminals and exogenous GABA added to the superfusion medium caused a long-lasting and concentration-dependent enhancement of the basal efflux of [3H]ACh.
γ‐Aminobutyric Acid Can Both Inhibit and Facilitate Dopamine Release in the Caudate Nucleus of the Rabbit
TLDR
The results indicate that y‐aminobutyric acid can both facilitate and depress the release of dopamine, and is probably mediated by a receptor site located in the membrane of these terminals.
Is there a functional linkage between neurotransmitter uptake mechanisms and presynaptic receptors?
TLDR
The present results do not support the previously proposed idea that in nerve terminals a functional coupling may exist between uptake mechanisms and presynaptic receptors.
Novel inhibitors of gamma-aminobutyric acid (GABA) uptake: anticonvulsant actions in rats and mice.
TLDR
The studies indicate that the family of compounds represented by SK&F 89976A andSK&F 100330A may have clinically relevant anticonvulsant activity.
...
1
2
3
4
...