Coexistence of antiphospholipid antibodies and cephalalgia

  title={Coexistence of antiphospholipid antibodies and cephalalgia},
  author={Md. Asiful Islam and F. Alam and S. Gan and C. Cavestro and K. Wong},
  pages={568 - 580}
Background The occurrence of antiphospholipid antibodies (aPLs) and headache comorbidity in the presence or absence of underlying autoimmune diseases remains unclear. Aim The aim of this review was to summarize the relationship between headache and aPLs based on evidences from cohort studies and case reports, in addition to examining the treatment strategies that resolved headache in aPLs-positive individuals. Methods A comprehensive literature search was conducted through PubMed, ISI Web of… Expand
5 Citations
Presence of Anticardiolipin Antibodies in Patients with Dementia: A Systematic Review and Meta-Analysis
Assessing the presence of aPLs in dementia patients without a diagnosis of any autoimmune disease suggested that aCL antibodies are generated due to the autoimmune-derived effects of dementia or there might be a potential causative role of this autoantibody in dementia pathogenesis. Expand
Antiphospholipid antibodies in epilepsy: A systematic review and meta-analysis.
Since none of the epilepsy subjects exhibited any comorbid autoimmune disorders, significant presence of aCL and anti-β2-GPI antibodies indicate towards their contribution in immune-mediated general pathogenesis of epilepsy. Expand
Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis
It is established that there is a significantly high prevalence of aPLs in patients with BD when compared to controls, and no significant publication bias was detected from contour-enhanced and trim and fill funnel plots or Begg's and Egger’s tests. Expand
Antiphospholipid antibodies and antiphospholipid syndrome in cancer: Uninvited guests in troubled times.
More researches should be conducted on the association between the aPLs and malignancies towards the potential impact on understanding the pathogenicity and treatment when cancer and APS coexists. Expand
Thrombophilic alterations, migraine, and vascular disease: results from a case-control study
A significative higher prevalence of aPL positivity and protein S deficiency in migraineurs than in controls is documented, and it is argued that thrombophilic disorders associated with migraine may contribute to the occurrence of vascular events. Expand


Migraineurs show a high prevalence of antiphospholipid antibodies
The data show that migraineurs have a significantly higher prevalence of antiphospholipid antibodies, and point towards the fact that the two conditions may be comorbid or even that migraine may be an early sign for identifying patients with aPL positivity. Expand
Antiphospholipid antibodies and antiphospholipid syndrome in 57 children and adolescents with systemic lupus erythematosus
The presence of APS was associated with haemolytic anaemia, leukopenia, thrombocytopenia, coagulation abnormalities, ischaemic cerebrovascularaccidents, amaurosis fugax, osteonecrosis and interstitial pneumonitis, and a negative association was observed between APS and the presence of anti-Ro antibodies. Expand
Neuropsychiatric manifestations in systemic lupus erythematosus: prevalence and association with antiphospholipid antibodies.
The new ACR criteria for NPSLE are useful to define NP manifestations in SLE with accuracy and are significantly associated with antiphospholipid antibodies, which are independently associated with CVD, headache, and seizures. Expand
[Antiphospholipid antibodies in children with migraine].
The mean values of aCL were within the normal range, therefore their role in pathogenesis of migraine remains unclear, and further observation is needed to assess the reliable role of higher values ofaCL in pathophysiology of vascular disorders. Expand
Antiphospholipid Antibodies and Migraine
Increased serum level of lgG anti β2GP1 among migraine patients was demonstrated and the frequency of migraine attacks correlated positively with the concentration of lGG antiβ2 GP1. Expand
Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins
Despite 95± power to detect a difference of 0.59 IgG units per litre in anticardiolipin antibody IgG titres, no difference in prevalence of aPL could be detected in migraine-discordant MZ twins. Expand
Clinical manifestations and antiphosphatidylserine antibodies in patients with systemic lupus erythematosus: is there an association?
It seems that isotypes of IgG, IgA, and IgM isotype of antibodies to cardiolipin (aCL) and antiphosphatidylserine (aPS) are correlated well with migraine and IgA aPS with thrombosis in SLE patients with secondary APS. Expand
Neurological antiphospholipid syndrome: Clinical, neuroimaging, and pathological characteristics
Neuroimaging and biopsy examination demonstrated that NAPS is an ischemic cerebrovascular disease caused by vascular stenosis or occlusion, and these characteristics might help to reduce the misdiagnosis of NAPS. Expand
Non-stroke Central Neurologic Manifestations in Antiphospholipid Syndrome
New findings about non-stroke NPM described in primary antiphospholipid syndrome and aPL-positive patients without overlap of other autoimmune diseases are summarized. Expand
Estimation of Antiphospholipid Antibodies in a Prospective Longitudinal Study of Children with Migraine
The prevalence of antiphospholipid antibodies (aPL) does not appear to be increased in an unselected group of children with migraine, however, the possible role of aPL in individual cases of paediatric migraine can not be excluded. Expand