Coexistence of anti-phospholipid antibodies and endothelial perturbation in systemic lupus erythematosus patients with ongoing prothrombotic state.

@article{Ferro1997CoexistenceOA,
  title={Coexistence of anti-phospholipid antibodies and endothelial perturbation in systemic lupus erythematosus patients with ongoing prothrombotic state.},
  author={Domenico Ferro and Valerio Pittoni and Concetta Quintarelli and Stefania Basili and Mirella Saliola and Constantino Caroselli and Guido Valesini and Francesco Violi},
  journal={Circulation},
  year={1997},
  volume={95 6},
  pages={
          1425-32
        }
}
BACKGROUND Anti-phospholipid antibodies (aPLs) were associated with an ongoing prothrombotic state in patients with systemic lupus erythematosus (SLE). Because aPLs are able to shift endothelial function toward procoagulant activity in vitro, we investigated the relationship among aPLs, ongoing prothrombotic state, and endothelial perturbation in SLE patients. METHODS AND RESULTS We measured aPLs, anti-EC antibodies, circulating levels of prothrombin fragment F1 + 2 (F1 + 2), tumor necrosis… CONTINUE READING
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