Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters A1 and G1

@article{Out2008CoexistenceOF,
  title={Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters A1 and G1},
  author={Ruud Out and Wendy Jessup and Wilfried Le Goff and Menno Hoekstra and Ingrid C Gelissen and Ying Zhao and Leonard Kritharides and Giovanna Chimini and Johan Kuiper and M. John Chapman and Thierry Huby and Th J C van Berkel and Miranda van Eck},
  journal={Circulation Research},
  year={2008},
  volume={102},
  pages={113-120}
}
The concept that macrophages can become foam cells as a result of a disturbed balance between the uptake of cholesterol from lipoproteins and cholesterol efflux is generally accepted. ABCA1 and ABCG1 are two cholesterol transporters that may act sequentially to remove cellular cholesterol, but currently their combined role in vivo is unknown. We report here that targeted disruption of both ABCA1 and ABCG1 in mice, despite severe plasma hypocholesterolemia, leads to massive lipid accumulation… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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