Coexistence of EGFR, KRAS, BRAF, and PIK3CA Mutations and ALK Rearrangement in a Comprehensive Cohort of 326 Consecutive Spanish Nonsquamous NSCLC Patients.

@article{Martorell2017CoexistenceOE,
  title={Coexistence of EGFR, KRAS, BRAF, and PIK3CA Mutations and ALK Rearrangement in a Comprehensive Cohort of 326 Consecutive Spanish Nonsquamous NSCLC Patients.},
  author={Paloma Mart{\'i}n Martorell and Marisol Huerta and Amparo Compa{\~n} Quilis and Rosario Abell{\'a}n and Enrique Seda and Sebasti{\'a}n Blesa and Felipe J. Chaves and Diego Dualde Beltr{\'a}n and Susana Rosell{\'o} Ker{\"a}nen and Jos{\'e} Ferreres Franco and Amelia Insa},
  journal={Clinical lung cancer},
  year={2017},
  volume={18 6},
  pages={
          e395-e402
        }
}
INTRODUCTION Molecular screening is crucial for the care of nonsquamous non-small-cell lung cancer (NSCLC) patients. The coexistence of mutations could have important consequences regarding treatment. We described the mutational patterns and coexistence among patients and their outcomes after targeted treatment. MATERIALS AND METHODS Data from consecutive patients with newly diagnosed nonsquamous NSCLC were prospectively collected. Next-generation sequencing analysis of mutational hotspots in… CONTINUE READING

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