Coevolution of tRNA intron motifs and tRNA endonuclease architecture in Archaea.

@article{TocchiniValentini2005CoevolutionOT,
  title={Coevolution of tRNA intron motifs and tRNA endonuclease architecture in Archaea.},
  author={Giuseppe D Tocchini-Valentini and Paolo Fruscoloni and Glauco P. Tocchini-Valentini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 43},
  pages={15418-22}
}
Members of the three kingdoms of life contain tRNA genes with introns. The introns in pre-tRNAs of Bacteria are self-splicing, whereas introns in archaeal and eukaryal pre-tRNAs are removed by splicing endonucleases. We have studied the structures of the endonucleases of Archaea and the architecture of the sites recognized in their pre-tRNA substrates. Three endonuclease structures are known in the Archaea: a homotetramer in some Euryarchaea, a homodimer in other Euryarchaea, and a… CONTINUE READING