Coevolution of persistently infecting small DNA viruses and their hosts linked to host-interactive regulatory domains.

@article{Shadan1993CoevolutionOP,
  title={Coevolution of persistently infecting small DNA viruses and their hosts linked to host-interactive regulatory domains.},
  author={Farhad F. Shadan and Luis P. Villarreal},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 9},
  pages={4117-21}
}
Although most RNA viral genomes (and related cellular retroposons) can evolve at rates a millionfold greater than that of their host genomes, some of the small DNA viruses (polyomaviruses and papillomaviruses) appear to evolve at much slower rates. These DNA viruses generally cause host species-specific inapparent primary infections followed by life-long, benign persistent infections. Using global progressive sequence alignments for kidney-specific Polyomaviridae (mouse, hamster, primate, human… CONTINUE READING