Coevolution of cyclin Pcl5 and its substrate Gcn4.

  title={Coevolution of cyclin Pcl5 and its substrate Gcn4.},
  author={Tsvia Gildor and Revital Shemer and Avigail Atir-Lande and Daniel Kornitzer},
  journal={Eukaryotic cell},
  volume={4 2},
Gcn4, a transcription factor that plays a key role in the response of Saccharomyces cerevisiae to amino acid starvation, is regulated at both the levels of translation and of protein stability. Regulated degradation of Gcn4 depends on its phosphorylation by the cyclin-dependent kinase Pho85, in conjunction with the cyclin Pcl5. The pathogenic yeast Candida albicans contains a functional homolog of Gcn4, which is involved in amino acid metabolism, as well as in the regulation of filamentous… CONTINUE READING


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