Coevolution between cannabinoid receptors and endocannabinoid ligands.

@article{McPartland2007CoevolutionBC,
  title={Coevolution between cannabinoid receptors and endocannabinoid ligands.},
  author={John M. McPartland and Ryan W. Norris and C. William Kilpatrick},
  journal={Gene},
  year={2007},
  volume={397 1-2},
  pages={126-35}
}
Genes for receptors and ligands must coevolve to maintain coordinated gene expression and binding affinities. Researchers have debated whether anandamide or 2-arachidonyl glycerol (2-AG) is a more "intrinsic" ligand of cannabinoid receptors. We addressed this debate with a coevolutionary analysis, by examining genes for CB1, CB2, and ten genes that encode ligand metabolic enzymes: abhydrolase domain containing 4 protein, cyclooxygenase 2, diacylglycerol lipase paralogs (DAGLalpha, DAGLbeta… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…