Coevolution between cannabinoid receptors and endocannabinoid ligands.

  title={Coevolution between cannabinoid receptors and endocannabinoid ligands.},
  author={John M. McPartland and Ryan W. Norris and C. William Kilpatrick},
  volume={397 1-2},
Genes for receptors and ligands must coevolve to maintain coordinated gene expression and binding affinities. Researchers have debated whether anandamide or 2-arachidonyl glycerol (2-AG) is a more "intrinsic" ligand of cannabinoid receptors. We addressed this debate with a coevolutionary analysis, by examining genes for CB1, CB2, and ten genes that encode ligand metabolic enzymes: abhydrolase domain containing 4 protein, cyclooxygenase 2, diacylglycerol lipase paralogs (DAGLalpha, DAGLbeta… CONTINUE READING


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