Coenzymes as fossils of an earlier metabolic state

@article{White2005CoenzymesAF,
  title={Coenzymes as fossils of an earlier metabolic state},
  author={H. B. White},
  journal={Journal of Molecular Evolution},
  year={2005},
  volume={7},
  pages={101-104}
}
  • H. B. White
  • Published 2005
  • Biology, Medicine
  • Journal of Molecular Evolution
SummaryA metabolic system composed of nucleic acid enzymes is proposed to have existed prior to the evolution of ribosomal protein synthesis. Vestiges of these nucleic acid enzymes persist in contemporary coenzymes. This proposal rationalizes the fact that many coenzymes are nucleotides or heterocyclic bases which could be derived from nucleotides. 
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References

SHOWING 1-10 OF 10 REFERENCES
Chemical and biological evolution of a nucleotide-binding protein
Three-dimensional alignment of the common nucleotide binding structure in dehydrogenases, kinases and flavodoxins permits the recognition of homologous amino acids when sequence comparisons aloneExpand
The evolution of dehydrogenases and kinases.
TLDR
The Evolution of Dehydrogenases and Kinase: Critical Reviews in Biochemistry: Vol. Expand
On earlier states of the biochemical system.
  • M. Yčas
  • Biology, Medicine
  • Journal of theoretical biology
  • 1974
TLDR
It is argued that to maintain function with a smaller number of enzymes, earlier enzymes must have been less specific, catalyzing classes of reactions that resulted in ambiguous translation, each cistron producing a family of related proteins. Expand
[Catalytic role for RNA in DNA replication].
  • N. Brewin
  • Biology, Medicine
  • Nature: New biology
  • 1972
TLDR
It seems likely that the machinery of DNA replication may have many features in common with the polynucleotide components of protein synthesis, and it seems unlikely that tRNA and rRNA arose by chance in a single evolutionary step, more probably they have evolved from the replicative machinery for polyn nucleotides. Expand
β structures of alternating polypeptides and their possible prebiotic significance
A survey of the commonest amino acids formed in prebiotic conditions suggests that the earliest form of genetic coding may have specified polypeptides with a strong tendency to form stable β-sheetExpand
A proposed model for interaction of polypeptides with RNA.
  • C. Carter, J. Kraut
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1974
TLDR
A model containing only standard bond lengths, bond angles, and dihedral angles is constructed in which a polypeptide double helix fits precisely into the minor groove of an RNA double helIX with identical helix parameters, and it is proposed that it played a fundamental role in the initiation of precellular evolution. Expand
Selforganization of matter and the evolution of biological macromolecules
TLDR
The causes and effect of cause and effect, and the prerequisites of Selforganization, are explained in more detail in the I.IA. Expand
Making Conferences Successful
Many features of the four-yearly Commonwealth Survey Officers' Conference contribute to its success and could be adopted with advantage by others.
Self-organization of molecular systems and evolution of the genetic apparatus.
  • H. Kuhn
  • Chemistry, Medicine
  • Angewandte Chemie
  • 1972
AN APPROACH TO THE EVOLUTION OF METABOLISM.
  • R. E. Eakin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1963