Coenzymes Q9 and Q10, vitamin E and peroxidation in rat synaptic and non-synaptic occipital cerebral cortex mitochondria during ageing.

@article{Battino2001CoenzymesQA,
  title={Coenzymes Q9 and Q10, vitamin E and peroxidation in rat synaptic and non-synaptic occipital cerebral cortex mitochondria during ageing.},
  author={Maurizio Battino and Stefano Bompadre and Luciana Leone and Roberto Federico Villa and Antonella Gorini},
  journal={Biological chemistry},
  year={2001},
  volume={382 6},
  pages={925-31}
}
Great attention has been devoted both to ageing phenomena at the mitochondrial level and to the antioxidant status of membrane structures. These kinds of investigations are difficult to perform in the brain because of its heterogeneity. It is known that synaptic heavy mitochondria (HM) may represent an aged mitochondrial population characterized by a partial impairment of their typical mitochondrial function. We arranged a novel system requiring no extraction procedure, very limited handling of… CONTINUE READING