Coenzyme Q10 supplementation in the management of statin‐associated myalgia

@article{Tan2017CoenzymeQS,
  title={Coenzyme Q10 supplementation in the management of statin‐associated myalgia},
  author={Jason Eng Thye Tan and Arden R. Barry},
  journal={American Journal of Health-System Pharmacy},
  year={2017},
  volume={74},
  pages={786,788,790–791,793}
}
  • J. Tan, A. Barry
  • Published 1 June 2017
  • Medicine
  • American Journal of Health-System Pharmacy
Statins are indicated for use as first-line therapy in the prevention of major adverse cardiovascular events (e.g., myocardial infarction, stroke) in patients with or at risk for cardiovascular disease.[1][1] However, muscle-related adverse effects, including myopathy, often limit the use of statins 
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References

SHOWING 1-10 OF 28 REFERENCES
Effect of coenzyme Q(10) supplementation on simvastatin-induced myalgia.
Coenzyme Q(10) and selenium in statin-associated myopathy treatment.
The objective of this study was to evaluate the possible benefits of coenzyme Q10 and selenium supplementation administered to patients with statin-associated myopathy (SAM). Sixty eligible patients
Effect of coenzyme Q10 supplementation on statin-induced myalgias.
The role of coenzyme Q10 in statin-associated myopathy: a systematic review.
Coenzyme Q10 Supplementation Decreases Statin-Related Mild-to-Moderate Muscle Symptoms: A Randomized Clinical Study
TLDR
Results show that coenzyme Q10 supplementation (50 mg twice daily) effectively reduced statin-related mild-to-moderate muscular symptoms, causing lower interference of statin -related muscular symptoms with daily activities.
An assessment of statin safety by muscle experts.
Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials.
Oral use of “Low and Slow” Rosuvastatin with Co-Enzyme Q10 in patients with Statin-Induced Myalgia: Retrospective case review
TLDR
“low and slow” rosuvastatin supplemented by co-enzyme Q10 led to clinically meaningful reductions in total and LDL-cholesterol in patients with statin-induced myalgia in a retrospective review of clinical practice.
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