Coenzyme Q10 supplementation in the management of statin‐associated myalgia

@article{Tan2017CoenzymeQS,
  title={Coenzyme Q10 supplementation in the management of statin‐associated myalgia},
  author={Jason Eng Thye Tan and Arden R. Barry},
  journal={American Journal of Health-System Pharmacy},
  year={2017},
  volume={74},
  pages={786,788,790–791,793}
}
  • J. Tan, A. Barry
  • Published 1 June 2017
  • Medicine
  • American Journal of Health-System Pharmacy
Statins are indicated for use as first-line therapy in the prevention of major adverse cardiovascular events (e.g., myocardial infarction, stroke) in patients with or at risk for cardiovascular disease.[1][1] However, muscle-related adverse effects, including myopathy, often limit the use of statins 
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Coenzyme Q10 for statin-associated myalgia.
TLDR
The authors omitted clinically relevant information and coenzyme Q10 supplementation in the management of statin-associated myalgia (SAM) and believe it plays a role in practice.
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The objective of this study was to evaluate the possible benefits of coenzyme Q10 and selenium supplementation administered to patients with statin-associated myopathy (SAM). Sixty eligible patients…
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The role of coenzyme Q10 in statin-associated myopathy: a systematic review.
Coenzyme Q10 Supplementation Decreases Statin-Related Mild-to-Moderate Muscle Symptoms: A Randomized Clinical Study
TLDR
Results show that coenzyme Q10 supplementation (50 mg twice daily) effectively reduced statin-related mild-to-moderate muscular symptoms, causing lower interference of statin -related muscular symptoms with daily activities.
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Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation
TLDR
It is concluded that statin‐related side effects, including statin cardiomyopathy, are far more common than previously published and are reversible with the combination of statin discontinuation and supplemental CoQ10.
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Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials.
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