Coenzyme Q10 supplementation in the management of statin‐associated myalgia

  title={Coenzyme Q10 supplementation in the management of statin‐associated myalgia},
  author={Jason Eng Thye Tan and Arden R. Barry},
  journal={American Journal of Health-System Pharmacy},
  • J. Tan, A. Barry
  • Published 1 June 2017
  • Medicine
  • American Journal of Health-System Pharmacy
Statins are indicated for use as first-line therapy in the prevention of major adverse cardiovascular events (e.g., myocardial infarction, stroke) in patients with or at risk for cardiovascular disease.[1][1] However, muscle-related adverse effects, including myopathy, often limit the use of statins 
Coenzyme Q10 for statin-associated myalgia.
The authors omitted clinically relevant information and coenzyme Q10 supplementation in the management of statin-associated myalgia (SAM) and believe it plays a role in practice.
Do PCSK9 inhibitors reduce cardiovascular events?
For patients with CVD taking maximally tolerated statins, adding evolocumab or alirocumab decreases new CVD events for an additional 1 in 65 patients.
Prevention and management of statin adverse effects: A practical approach for pharmacists
A thorough assessment of patients’ clinical and laboratory history should be performed in any patient presenting with muscle symptoms on statin therapy, followed by a systematic dechallenge/rechallenge approach, ensuring patients are appropriately receiving a statin and aware of both the benefits and risks of therapy.
The Interplay between Oxidative Stress, Exercise, and Pain in Health and Disease: Potential Role of Autonomic Regulation and Epigenetic Mechanisms
The relation between oxidative stress, exercise, and pain is poorly understood and not straightforward, as it is dependent on the characteristics of exercise, but also on which population is investigated, and strict guidelines should be developed to limit the effect of several confounding factors.
Stability of Reduced and Oxidized Coenzyme Q10 in Finished Products
Proper coenzyme Q10 stabilization through final formulations regardless of the used CoQ10 form is needed, as conversion and inappropriate content in products, which specify ubiquinone, are unacceptable in terms of regulation.


Effect of coenzyme Q(10) supplementation on simvastatin-induced myalgia.
Coenzyme Q(10) and selenium in statin-associated myopathy treatment.
The objective of this study was to evaluate the possible benefits of coenzyme Q10 and selenium supplementation administered to patients with statin-associated myopathy (SAM). Sixty eligible patients
Effect of coenzyme Q10 supplementation on statin-induced myalgias.
The role of coenzyme Q10 in statin-associated myopathy: a systematic review.
Coenzyme Q10 Supplementation Decreases Statin-Related Mild-to-Moderate Muscle Symptoms: A Randomized Clinical Study
Results show that coenzyme Q10 supplementation (50 mg twice daily) effectively reduced statin-related mild-to-moderate muscular symptoms, causing lower interference of statin -related muscular symptoms with daily activities.
An assessment of statin safety by muscle experts.
Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials.
Oral use of “Low and Slow” Rosuvastatin with Co-Enzyme Q10 in patients with Statin-Induced Myalgia: Retrospective case review
“low and slow” rosuvastatin supplemented by co-enzyme Q10 led to clinically meaningful reductions in total and LDL-cholesterol in patients with statin-induced myalgia in a retrospective review of clinical practice.