Coenzyme Q10 enhances dermal elastin expression, inhibits IL‐1α production and melanin synthesis in vitro

@article{Zhang2012CoenzymeQE,
  title={Coenzyme Q10 enhances dermal elastin expression, inhibits IL‐1$\alpha$ production and melanin synthesis in vitro},
  author={M. Zhang and Liu Dang and Fangrong Guo and X. Wang and W. Zhao and R. Zhao},
  journal={International Journal of Cosmetic Science},
  year={2012},
  volume={34}
}
Coenzyme Q10 (CoQ10) is a well‐known antioxidant and has been used in many skincare products for anti‐ageing purpose. However, the molecular mechanisms of CoQ10 function in skin cells are not fully understood. In this paper, we compared the effects of CoQ10 on primary human dermal fibroblasts from three individuals, including adult. We demonstrated that CoQ10 treatment promoted proliferation of fibroblasts, increased type IV collagen expression and reduced UVR‐induced matrix metalloproteinases… 
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34 Citations
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34 Citations

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Citation Type

Stimulatory effects of collagen production induced by coenzyme Q10 in cultured skin fibroblasts
TLDR
CoQ 10 has the efficacy that it increases collagen production in skin, thereby there is possible of the anti-aging by CoQ 10 in Japan which reached an aging society, so that it might be based on new physiological function by Co Q 10.
The in vitro and in vivo depigmenting activity of Coenzyme Q10 through the down-regulation of α-MSH signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated skin keratinocytes.
Anti-ageing effects of Ubiquinone and Ubiquinol in a senescence model of human dermal fibroblasts.
Improving the anti-ageing activity of coenzyme Q10 through protransfersome-loaded emulgel
TLDR
The in vivo study revealed that Protransf-CoQ10 Emulgel successfully increases the collagen density and number of fibroblast cells in UV radiation skin-aged induced-mice which reflects its potential for repairing the skin ageing process.
Avaliação da eficácia in vivo da L-arginina na elasticidade da pele
TLDR
The results suggested that the application of L-arginine improves the skin resistance to traction force in female elder mice and L- arginine promotes the formation of a higher amount of collagen and elastic fibers in the skin when applied at a concentration of 15%.
A cytokine axis regulates elastin formation and degradation.
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  • Biology, Medicine
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  • 2013
Potential therapeutic role of Co‐Q10 in alleviating intervertebral disc degeneration and suppressing IL‐1&bgr;‐mediated inflammatory reaction in NP cells
The Use of Coenzyme Q10 in Cardiovascular Diseases
TLDR
Clinical evidence shows that CoQ10 supplementation for prolonged periods is safe, well-tolerated and significantly increases the concentration of CoQ8 in plasma up to 3–5 µg/mL, and increases the NO levels for vasodilation.
Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines
TLDR
The findings suggest that the combined formulation may have the potential to powerfully inhibit oxidative stress and inflammation at skin level.
Coenzyme Q10 Supplementation as an Adjuvant Therapy Potentially Increase Serum Superoxide Dismutase Levels in Acne Vulgaris Patients
TLDR
CoQ10 supplementation can increase serum SOD levels and improve the severity of AV, a chronic inflammatory disease in the pilosebaceous unit, and the use of antioxidants like coenzyme Q10 as adjuvant therapy is expected to be beneficial for AV.
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