Coenzyme Q10 enhances dermal elastin expression, inhibits IL‐1α production and melanin synthesis in vitro

@article{Zhang2012CoenzymeQE,
  title={Coenzyme Q10 enhances dermal elastin expression, inhibits IL‐1$\alpha$ production and melanin synthesis in vitro},
  author={M. Zhang and Liu Dang and Fangrong Guo and X. Wang and W. Zhao and R. Zhao},
  journal={International Journal of Cosmetic Science},
  year={2012},
  volume={34}
}
Coenzyme Q10 (CoQ10) is a well‐known antioxidant and has been used in many skincare products for anti‐ageing purpose. However, the molecular mechanisms of CoQ10 function in skin cells are not fully understood. In this paper, we compared the effects of CoQ10 on primary human dermal fibroblasts from three individuals, including adult. We demonstrated that CoQ10 treatment promoted proliferation of fibroblasts, increased type IV collagen expression and reduced UVR‐induced matrix metalloproteinases… 
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35 Citations
Background Citations
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35 Citations

Stimulatory effects of collagen production induced by coenzyme Q10 in cultured skin fibroblasts
TLDR
CoQ10 treatment increased intracellular CoQ10 level and promoted proliferation of fibroblasts and increased mRNA expression of type I, IV, VII collagen, elastin, and HSP47, whereas Co Q10 has little effect on mRNA of type II and VIII MMP.
The in vitro and in vivo depigmenting activity of Coenzyme Q10 through the down-regulation of α-MSH signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated skin keratinocytes.
Anti-ageing effects of Ubiquinone and Ubiquinol in a senescence model of human dermal fibroblasts.
Avaliação da eficácia in vivo da L-arginina na elasticidade da pele
TLDR
The results suggested that the application of L-arginine improves the skin resistance to traction force in female elder mice and L- arginine promotes the formation of a higher amount of collagen and elastic fibers in the skin when applied at a concentration of 15%.
Potential therapeutic role of Co‐Q10 in alleviating intervertebral disc degeneration and suppressing IL‐1&bgr;‐mediated inflammatory reaction in NP cells
The Use of Coenzyme Q10 in Cardiovascular Diseases
TLDR
Clinical evidence shows that CoQ10 supplementation for prolonged periods is safe, well-tolerated and significantly increases the concentration of CoQ8 in plasma up to 3–5 µg/mL, and increases the NO levels for vasodilation.
Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines
TLDR
The findings suggest that the combined formulation may have the potential to powerfully inhibit oxidative stress and inflammation at skin level.
Coenzyme Q10 Supplementation as an Adjuvant Therapy Potentially Increase Serum Superoxide Dismutase Levels in Acne Vulgaris Patients
TLDR
CoQ10 supplementation can increase serum SOD levels and improve the severity of AV, a chronic inflammatory disease in the pilosebaceous unit, and the use of antioxidants like coenzyme Q10 as adjuvant therapy is expected to be beneficial for AV.
Protective effect of porphyra-334 on UVA-induced photoaging in human skin fibroblasts
TLDR
The results suggest that porphyra-334 has various applications in cosmetics and toiletries because of its anti-photoaging activities and may serve as a novel anti-aging agent.
The Role of Interleukin‐1 in Inflammatory and Malignant Human Skin Diseases and the Rationale for Targeting Interleukin‐1 Alpha
TLDR
An overview on IL‐1α and IL‐β functions, and their contribution to inflammatory and malignant skin diseases is provided and it is hypothesized that this isoform is a promising drug target for the treatment and prevention of many skin diseases.
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References

SHOWING 1-10 OF 50 REFERENCES
Coenzyme Q10 protects against oxidative stress‐induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells
TLDR
Protecting epidermis against oxidative stress and enhancement of production of epidermal basement membrane components may be involved in the antiaging properties of CoQ10 in skin.
A novel anti‐ageing mechanism for retinol: induction of dermal elastin synthesis and elastin fibre formation
TLDR
It is shown that retinol (ROL), known to enhance dermal collagen production, is also enhancing elastin fibre formation in cultured human dermal fibroblasts, demonstrating that ROL exerts its anti‐ageing benefits not only via enhanced epidermal proliferation and increased collagenproduction, but also through an increase inElastin production and assembly.
LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression
TLDR
LOXL can be considered as a new target to reinduce elastogenesis at the adult age, because its stimulation by a dill extract is correlated with increased elastin detection, suggesting an increase inElastogenesis efficiency.
The pathogenesis of photoaging: the role of neutrophils and neutrophil-derived enzymes.
TLDR
Clinical data indicate that high(er) doses ofUV, IR, and heat are necessary to induce photoaging or photoaging-like pathology in the skin, and it is proposed that MMPs generated by suberythemogenic doses of UV and low doses of IR/heat are involved in cellular processes other than ECM degradation.
Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effects.
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
TLDR
It is proposed that elevated metalloprotein-ases, resulting from activation of AP-1 and NF-KB by low-dose solar irradiation, degrade collagen and elastin in skin, which would result in solar scars, which through accumulation from a lifetime of repeated low- dose sunlight exposure could cause premature skin ageing (photoageing).
Extracts from Glycine max (soybean) induce elastin synthesis and inhibit elastase activity
TLDR
The studies show that non‐denatured Glycine max (soybean) extracts induced elastin promoter activity, inhibited elastase activity and protected elastic fibres from degradation by exogenous elastases in vitro, suggesting that non-denaturing soybean extracts may be used as skin care agents to reduce the signs of skin ageing.
UVB‐irradiated human keratinocytes and interleukin‐1&agr; indirectly increase MAP kinase/AP‐1 activation and MMP‐1 production in UVA‐irradiated dermal fibroblasts
TLDR
IL‐1 may play an important role in the paracrine activation and dermal collagen excessive degradation leading to skin photoaging by indirectly promoting MMP‐1 production in UVA‐irradiated fibroblasts by increasing MAP kinase/AP‐1 activity.
Coenzyme Q10 inhibits mitochondrial complex‐1 down‐regulation and nuclear factor‐kappa B activation
TLDR
It is suggested that enhancing coenzyme Q10 synthesis and suppressing the induction of NF‐kappa B, may provide neuroprotection.
The advantages of a novel CoQ10 delivery system in skin photo-protection.
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