Coenzyme Q10 enhances dermal elastin expression, inhibits IL‐1α production and melanin synthesis in vitro

@article{Zhang2012CoenzymeQE,
  title={Coenzyme Q10 enhances dermal elastin expression, inhibits IL‐1$\alpha$ production and melanin synthesis in vitro},
  author={M. Zhang and Liu Dang and Fangrong Guo and X. Wang and W. Zhao and R. Zhao},
  journal={International Journal of Cosmetic Science},
  year={2012},
  volume={34}
}
Coenzyme Q10 (CoQ10) is a well‐known antioxidant and has been used in many skincare products for anti‐ageing purpose. However, the molecular mechanisms of CoQ10 function in skin cells are not fully understood. In this paper, we compared the effects of CoQ10 on primary human dermal fibroblasts from three individuals, including adult. We demonstrated that CoQ10 treatment promoted proliferation of fibroblasts, increased type IV collagen expression and reduced UVR‐induced matrix metalloproteinases… 
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An overview on IL‐1α and IL‐β functions, and their contribution to inflammatory and malignant skin diseases is provided and it is hypothesized that this isoform is a promising drug target for the treatment and prevention of many skin diseases.
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