Coenzyme Q10 enhances dermal elastin expression, inhibits IL‐1α production and melanin synthesis in vitro

@article{Zhang2012CoenzymeQE,
  title={Coenzyme Q10 enhances dermal elastin expression, inhibits IL‐1$\alpha$ production and melanin synthesis in vitro},
  author={M. Zhang and Liu Dang and Fangrong Guo and X. Wang and W. Zhao and R. Zhao},
  journal={International Journal of Cosmetic Science},
  year={2012},
  volume={34}
}
Coenzyme Q10 (CoQ10) is a well‐known antioxidant and has been used in many skincare products for anti‐ageing purpose. However, the molecular mechanisms of CoQ10 function in skin cells are not fully understood. In this paper, we compared the effects of CoQ10 on primary human dermal fibroblasts from three individuals, including adult. We demonstrated that CoQ10 treatment promoted proliferation of fibroblasts, increased type IV collagen expression and reduced UVR‐induced matrix metalloproteinases… 
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References

SHOWING 1-10 OF 50 REFERENCES
Coenzyme Q10 protects against oxidative stress‐induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells
TLDR
Protecting epidermis against oxidative stress and enhancement of production of epidermal basement membrane components may be involved in the antiaging properties of CoQ10 in skin.
A novel anti‐ageing mechanism for retinol: induction of dermal elastin synthesis and elastin fibre formation
TLDR
It is shown that retinol (ROL), known to enhance dermal collagen production, is also enhancing elastin fibre formation in cultured human dermal fibroblasts, demonstrating that ROL exerts its anti‐ageing benefits not only via enhanced epidermal proliferation and increased collagenproduction, but also through an increase inElastin production and assembly.
LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression
TLDR
LOXL can be considered as a new target to reinduce elastogenesis at the adult age, because its stimulation by a dill extract is correlated with increased elastin detection, suggesting an increase inElastogenesis efficiency.
The pathogenesis of photoaging: the role of neutrophils and neutrophil-derived enzymes.
TLDR
Clinical data indicate that high(er) doses ofUV, IR, and heat are necessary to induce photoaging or photoaging-like pathology in the skin, and it is proposed that MMPs generated by suberythemogenic doses of UV and low doses of IR/heat are involved in cellular processes other than ECM degradation.
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
TLDR
It is proposed that elevated metalloprotein-ases, resulting from activation of AP-1 and NF-KB by low-dose solar irradiation, degrade collagen and elastin in skin, which would result in solar scars, which through accumulation from a lifetime of repeated low- dose sunlight exposure could cause premature skin ageing (photoageing).
Extracts from Glycine max (soybean) induce elastin synthesis and inhibit elastase activity
TLDR
The studies show that non‐denatured Glycine max (soybean) extracts induced elastin promoter activity, inhibited elastase activity and protected elastic fibres from degradation by exogenous elastases in vitro, suggesting that non-denaturing soybean extracts may be used as skin care agents to reduce the signs of skin ageing.
UVB‐irradiated human keratinocytes and interleukin‐1&agr; indirectly increase MAP kinase/AP‐1 activation and MMP‐1 production in UVA‐irradiated dermal fibroblasts
TLDR
IL‐1 may play an important role in the paracrine activation and dermal collagen excessive degradation leading to skin photoaging by indirectly promoting MMP‐1 production in UVA‐irradiated fibroblasts by increasing MAP kinase/AP‐1 activity.
Coenzyme Q10 inhibits mitochondrial complex‐1 down‐regulation and nuclear factor‐kappa B activation
TLDR
It is suggested that enhancing coenzyme Q10 synthesis and suppressing the induction of NF‐kappa B, may provide neuroprotection.
The advantages of a novel CoQ10 delivery system in skin photo-protection.
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