Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.

@article{Dumont2011CoenzymeQD,
  title={Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.},
  author={Magali Dumont and Khatuna Kipiani and Fangmin Yu and Elizabeth J. Wille and Maya Balakirsky Katz and Noel Ylagan Calingasan and Gunnar Gouras and Michael T. Lin and Myron Flint Beal},
  journal={Journal of Alzheimer's disease : JAD},
  year={2011},
  volume={27 1},
  pages={211-23}
}
Increased oxidative stress is implicated in the pathogenesis of Alzheimer's disease (AD). A large body of evidence suggests that mitochondrial dysfunction and increased reactive oxygen species occur prior to amyloid-β (Aβ) deposition. Coenzyme Q10 (CoQ10), a component of the mitochondrial electron transport chain, is well characterized as a neuroprotective antioxidant in animal models and human trials of Huntington's disease and Parkinson's disease, and reduces plaque burden in AβPP/PS1 mice… CONTINUE READING

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