Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress.

  title={Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress.},
  author={Naoaki Ishii and Nanami Senoo-Matsuda and Kohichiro Miyake and Kayo Yasuda and Takamasa Ishii and Philip S. Hartman and Satoru Furukawa},
  journal={Mechanisms of ageing and development},
  volume={125 1},
The mev-1 gene encodes cytochrome b, a large subunit of the Complex II enzyme succinate-CoQ oxidoreductase. The mev-1(kn1) mutants are hypersensitive to oxidative stress and age precociously, probably because of elevated superoxide anion production in mitochondria. Coenzyme Q (CoQ) is essential for the mitochondrial respiratory chain. Here, we show that CoQ(10) and Vitamin E extended the life span of wild-type Caenorhabditis elegans. Conversely, only CoQ(10) recovered the life shortening… CONTINUE READING


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