Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat.

@article{Mohamed2019CoenzymeQA,
  title={Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat.},
  author={Doaa I. Mohamed and E. Khairy and Sherin Shafik Tawfek and E. Habib and Marwa A Fetouh},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2019},
  volume={109},
  pages={
          892-901
        }
}
  • Doaa I. Mohamed, E. Khairy, +2 authors Marwa A Fetouh
  • Published 2019
  • Biology, Medicine
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • The present study was conducted to investigate the potential protective effects of coenzyme Q 10 (CoQ10) administration on methotrexate induced lung and liver fibrosis in rat model, and to explore our hypothesis regarding its possible mechanism of action through reactivation of autophagy pathway. Methotrexate induced fibrosis was achieved by intraperitoneal injections twice a week for 4 weeks. A combined treatment of CoQ10 and methotrexate were used. Blood samples for biochemical analysis, lung… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 44 REFERENCES
    Autophagy in Idiopathic Pulmonary Fibrosis
    223