Coenzyme Q10 and Heart Failure: A State-of-the-Art Review

@article{Sharma2016CoenzymeQA,
  title={Coenzyme Q10 and Heart Failure: A State-of-the-Art Review},
  author={Abhinav Sharma and G. Fonarow and Javed Butler and Justin A. Ezekowitz and G. Michael Felker},
  journal={Circulation: Heart Failure},
  year={2016},
  volume={9},
  pages={e002639}
}
Heart failure (HF) with either preserved or reduced ejection fraction is associated with increased morbidity and mortality. Evidence-based therapies are often limited by tolerability, hypotension, electrolyte disturbances, and renal dysfunction. Coenzyme Q10 (CoQ10) may represent a safe therapeutic option for patients with HF. CoQ10 is a highly lipophilic molecule with a chemical structure similar to vitamin K. Although being a common component of cellular membranes, CoQ10’s most prominent role… 

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References

SHOWING 1-10 OF 67 REFERENCES
Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
TLDR
It is demonstrated that the addition of coenzyme Q10 to conventional therapy significantly reduces hospitalization for worsening of heart failure and the incidence of serious complications in patients with chronic congestive heart failure.
The Effect of Coenzyme Q10 in Patients with Congestive Heart Failure
TLDR
The effects of coenzyme Q10 supplementation on left ventricular ejection fraction and exercise tolerance in patients with symptomatic heart failure despite standard medical therapy were evaluated.
Coenzyme Q10: an independent predictor of mortality in chronic heart failure.
The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure Results From Q-SYMBIO : A Randomized Double-Blind Trial
TLDR
Long-term CoQ10 treatment of patients with chronic HF is safe, improves symptoms, and reduces major adverse cardiovascular events, as determined by a time to first event analysis.
Myocardial energetics and ubiquinol in diastolic heart failure.
TLDR
Clinicians and health scientists should be aware of the potential role of this supplement, ubiquinol, which is an antioxidant and is required for adenosine triphosphate production, in the treatment of diastolic heart failure.
Effect of coenzyme Q 10 supplementation on heart failure : a meta-analysis 1 – 3 A
TLDR
Pooled analyses of available randomized controlled trials suggest that CoQ10 may improve the ejection fraction in patients with CHF.
Effect of coenzyme Q₁₀ supplementation on heart failure: a meta-analysis.
TLDR
Pooled analyses of available randomized controlled trials suggest that CoQ₁₀ may improve the EF in patients with CHF.
Coenzyme Q10 (CoQ10) in isolated diastolic heart failure in hypertrophic cardiomyopathy (HCM)
TLDR
There was a significant improvement in the parameters like NYHA class ≥ 1, in quality of life (QOL) on 6 minutes walk test, in diastolic dysfunction by ≥1 parameter and in MR ≥ 1 grade and a significant reduction in left ventricular outflow tract gradient in obstructive cases in the treatment group.
...
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