Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics

@article{Bhagavan2006CoenzymeQA,
  title={Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics},
  author={Hemmi N. Bhagavan and Raj K. Chopra},
  journal={Free Radical Research},
  year={2006},
  volume={40},
  pages={445 - 453}
}
Available data on the absorption, metabolism and pharmacokinetics of coenzyme Q10 (CoQ10) are reviewed in this paper. [] Key Result The T(max) is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma CoQ10 range from 0.40 to 1.91 micromol/l in healthy adults. With CoQ10 supplements there is reasonable correlation between increase in plasma CoQ10 and ingested dose up to a certain point. Animal data show that CoQ10 in large doses is taken up by all tissues including heart…
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  • Biology
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The use of CoQ10 in various cardiac and tumor conditions indicates that its activity is not only due to its antioxidant activity but alsodue to its apoptosis property.
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