Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics
@article{Bhagavan2006CoenzymeQA, title={Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics}, author={Hemmi N. Bhagavan and Raj K. Chopra}, journal={Free Radical Research}, year={2006}, volume={40}, pages={445 - 453} }
Available data on the absorption, metabolism and pharmacokinetics of coenzyme Q10 (CoQ10) are reviewed in this paper. [] Key Result The T(max) is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma CoQ10 range from 0.40 to 1.91 micromol/l in healthy adults. With CoQ10 supplements there is reasonable correlation between increase in plasma CoQ10 and ingested dose up to a certain point. Animal data show that CoQ10 in large doses is taken up by all tissues including heart…
421 Citations
Clinical applications of coenzyme Q10.
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Recent data indicate that CoQ10 affects expression of genes involved in human cell signalling, metabolism and transport and some of the effects of CoQ20 supplementation may be due to this property, which may provide a significant symptomatic benefit.
Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization.
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Coenzyme Q10 supplementation – In ageing and disease
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Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals
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No differences in the redox status of the absorbed coenzyme Q10 were observed between formulations, showing that CoQ10 appeared in the blood mostly as ubiquinol, even if consumed as ubiqu inone.
Coenzyme Q10 effects in neurological diseases.
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It seems reasonable to recommend CoQ10 as adjunct to conventional therapy in some cases, however, sometimes CoQ 10 supplementations are more efficient in animal models of diseases than in human patients (e.g. Parkinson´s disease).
Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations
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- 2010
Oral CoQ10 is a viable antioxidant strategy in many diseases, providing a significant to mild symptomatic benefit and Idebenone and MitoQ are promising substitutive Coq10-related drugs which are well tolerated and safe.
Pharmacokinetics and Tissue Distribution of Oxidized and Reduced Coenzyme Q10 Upon Intravenous Administration
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- 2021
It was found that replenishment of the CoQ10 tissue content in individual organs was equally successful despite different total clearances of ubiquinol and ubiquinone, which implied they were equally effective upon intravenous administration.
The Plasma Bioavailability of Coenzyme Q10 Absorbed from the Gut and the Oral Mucosa
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- 2018
It is concluded that the intestinal absorption of CoQ10 is highly variable and is independent of the molecular form administered, and liposomes are not an effective vehicle for the oral administration of Coq10, and as such did not improve the oral mucosal/sublingual absorption and bioavailability of the molecule.
Coenzyme Q10: Regulators of Mitochondria and beyond
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The use of CoQ10 in various cardiac and tumor conditions indicates that its activity is not only due to its antioxidant activity but alsodue to its apoptosis property.
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