Coenzyme Q10: A therapy for hypertension and statin-induced myalgia?

@article{Wyman2010CoenzymeQA,
  title={Coenzyme Q10: A therapy for hypertension and statin-induced myalgia?},
  author={Marcia J. Wyman and Mandy C. Leonard and Thomas J. Morledge},
  journal={Cleveland Clinic Journal of Medicine},
  year={2010},
  volume={77},
  pages={435 - 442}
}
Some small clinical trials seem to show that coenzyme Q10 supplements can be used to lower blood pressure and to treat or prevent myalgia caused by hydroxymethylglutaryl coenzyme A reductase inhibitors (statins). However, larger trials are needed to determine if they are truly effective for these purposes. The authors examine the evidence and also discuss issues such as bioavailability, elimination, safety, and cost. These supplements appear to be safe, but larger trials are needed to determine… 
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Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials.
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A review of clinical efficacy trials using CoQ10 is provided and recent advances in formulation technology to improve the bioavailability of CoQ 10 are described to help clinicians and consumers make informed decisions.
Effects of Coenzyme Q 10 on Statin-Induced Myopathy : A Meta-analysis of Randomized Controlled Trials
TLDR
The results of this meta-analysis of available randomized controlled trials do not suggest any significant benefit of CoQ10 supplementation in improving statin-induced myopathy and larger, welldesigned trials are necessary to confirm the findings.
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Results show that coenzyme Q10 supplementation (50 mg twice daily) effectively reduced statin-related mild-to-moderate muscular symptoms, causing lower interference of statin -related muscular symptoms with daily activities.
Coenzyme Q10 supplementation in patients with rheumatoid arthritis: Are there any effects on cardiovascular risk factors?
Genetic and immunologic susceptibility to statin-related myopathy.
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Emerging evidence supports that administration of CoQ10 may have beneficial effects at the mitochondrial level and the cellular mechanisms of Co Q10 and the administration ofCoQ10 in different clinical disease states are emphasized.
Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia
TLDR
The results of this pilot study suggest the possible beneficial effects of triple combination on the lipid and non-lipid parameters related to atherogenesis and side effects of statin treatment.
Application of Coenzyme Q10 in Clinical Practice
TLDR
Emerging evidence supports that administration of CoQ10 may have beneficial effects at the mitochondrial level and the cellular mechanisms of Co Q10 and the administration ofCoQ10 in different clinical disease states are emphasized.
Reversal of statin-induced memory dysfunction by co-enzyme Q10: a case report
TLDR
It is being recommended for use for use when statin side effects (muscle- and memory-related) impair quality of life and leave patient at dyslipidemia-induced cardiovascular morbi-mortality.
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References

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TLDR
The development of a standardized system for description and documentation of statin-associated myopathy that includes the entire spectrum of muscle complaints would provide valuable data for researchers and clinicians seeking to better understandstatin-induced muscle complaints.
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TLDR
There is evidence to support the therapeutic value of CoQ10 as an adjunct to standard medical therapy in congestive heart failure, however, much further research is required, especially in the use of state-of-the-art techniques to assess functional outcomes in patients with congestiveheart failure.
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TLDR
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TLDR
There is a significant correlation between the CoQ10 level decrease and the decrease in total and LDL-C levels in all three treatment groups, suggesting that the Co Q10 decrease may reflect the decreaseIn the levels of its lipoprotein carriers and might not be statin-specific.
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TLDR
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TLDR
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