Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans.

@article{Arroyo2006CoenzymeQI,
  title={Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans.},
  author={Antonio Arroyo and Carlos Santos-Oca{\~n}a and Macarena Ruiz-Ferrer and Sergio Padilla and Angela Gavil{\'a}n and Juan Carlos Rodr{\'i}guez-Aguilera and Pl{\'a}cido Navas},
  journal={FEBS letters},
  year={2006},
  volume={580 7},
  pages={1740-6}
}
A procedure was developed to isolate fractions enriched in plasma membrane from Caenorhabditis elegans. Coenzyme Q9 (Q9) was found in plasma membrane isolated from either wild-type or long-lived qm30 and qm51 clk-1 mutant strains of Caenorhabditis elegans, along with dietary coenzyme Q8 (Q8) and the biosynthetic intermediate demethoxy-Q9 (DMQ9). NADH was able to reduce both Q8 and Q9, but not DMQ9. Our results indicate that DMQ9 cannot achieve the same redox role of Q9 in plasma membrane… CONTINUE READING

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