• Corpus ID: 43938558

Coenzyme Q 10 in cardiovascular disease

@article{Pepe2007CoenzymeQ1,
  title={Coenzyme Q 10 in cardiovascular disease},
  author={Salvatore Pepe and Silvana F. Marasco and Steven Joseph Haas and Freya L. Sheeran and Henry Krum and Franklin Rosenfeldt},
  journal={Mitochondrion},
  year={2007}
}
In this review we summarise the current state of knowledge of the therapeutic efficacy and mechanisms of action of CoQ10 in cardiovascular disease. Our conclusions are: 1. There is promising evidence of a beneficial effect of CoQ10 when given alone or in addition to standard therapies in hypertension and in heart failure, but less extensive evidence in ischemic heart disease. 2. Large scale multi-centre prospective randomised trials are indicated in all these areas but there are difficulties in… 

Figures and Tables from this paper

The Use of Coenzyme Q10 in Cardiovascular Diseases
TLDR
Clinical evidence shows that CoQ10 supplementation for prolonged periods is safe, well-tolerated and significantly increases the concentration of CoQ8 in plasma up to 3–5 µg/mL, and increases the NO levels for vasodilation.
Heart Failure—Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10
TLDR
Long-term coenzyme Q10 supplementation at a dose of 300 mg/day (Q-SYMBIO study) has been shown to significantly improve heart function and prognosis in patients with HF and is an important predictor of the risk of death.
Coenzyme Q 10 supplementation reduces oxidative stress and increase antioxidant enzyme activity in patients with coronary artery disease
TLDR
Coenzyme Q10 supplements at a dose of 150 mg can decrease oxidative stress and increase antioxidant enzyme activity in patients with CAD and a higher dose of coenzymeQ10 supplements (>150 mg/d) might promote rapid and sustainable antioxidation in patientswith CAD.
tatin therapy and plasma coenzyme Q 10 concentrations — A ystematic review and meta-analysis of placebo-controlled trials
TLDR
The impact of statin therapy on plasma CoQ10 concentrations was assessed through the meta-analysis of available RCTs through the literature search and the pooled effect size was robust and remained significant in the leave-one-out sensitivity analysis.
Coenzyme Q10 Supplements’ Knowledge among Cardiac Patients
TLDR
The obtained knowledge towards Coenzyme Q10 supplements reflected the low pattern of use among cardiac patients and emphasized the role of healthcare providers to increase awareness about the benefits of Coen enzyme Q10 supplement as well as to educate them about its interaction with some drugs.
Effect of Coenzyme Q10 Supplementation on Testosterone
TLDR
Coenzyme Q10 supplementation was found to ameliorate the reduction in testosterone induced by chemical reproductive toxicants, mainly by neutralizing the damaging effect of the generated free radicals, but collectively these findings require further confirmation by additional research studies.
Dietary Composition and Cardiovascular Risk: A Mediator or a Bystander?
TLDR
This review aims to present the most recent data concerning different dietary patterns at both the macro- and micronutrient level and their association with atherosclerosis, obesity, and other risk factors for cardiovascular disease.
...
...

References

SHOWING 1-10 OF 157 REFERENCES
Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
TLDR
It is demonstrated that the addition of coenzyme Q10 to conventional therapy significantly reduces hospitalization for worsening of heart failure and the incidence of serious complications in patients with chronic congestive heart failure.
Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials
TLDR
It is concluded that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolicBlood pressure by 10  mm Hg without significant side effects.
Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials.
Coenzyme Q10 and exercise training in chronic heart failure.
TLDR
Oral CoQ(10) improves functional capacity, endothelial function, and LV contractility in CHF without any side effects and significant synergistic effect of CoQ (10) with ET was observed only for peak SWTI suggesting that ET amplifies the already described effect of coenzyme Q( 10) on contractility of dysfunctional myocardium.
Randomized, Double-Blind, Placebo- Controlled Trial of Coenzyme Q10 in Isolated Systolic Hypertension
TLDR
The results suggest CoQ may be safely offered to hypertensive patients as an alternative treatment option, and the antihypertensive effectiveness of CoQ, an over-the-counter nutritional supplement, is evaluated.
Overview on coenzyme Q10 as adjunctive therapy in chronic heart failure. Rationale, design and end‐points of “Q‐symbio” ‐ A multinational trial
TLDR
A reduced myocardial tissue content of the essential redox‐component and natural antioxidant Coenzyme Q10 (CoQ10) has been detected in patients with heart failure and the observed level of CoQ10 deficiency was correlated to the severity of heart failure.
Ubiquinone (coenzyme Q10) in the long-term treatment of idiopathic dilated cardiomyopathy.
TLDR
Chronic treatment with ubiquinone had no influence on haemodynamic parameters, electrocardiogram, incidence of ventricular arrhythmias or on exercise tolerance, and it was therefore impossible to demonstrate any therapeutic effect of ubiquin one in patients suffering from idiopathic dilated cardiomyopathy.
Treatment of essential hypertension with coenzyme Q10.
Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure.
TLDR
This pilot study accords with published data suggesting that CoQ10 therapy improves cardiac functional status in patients with moderately severe dilated cardiomyopathy receiving maximal non beta-blocker therapy.
...
...