Coenzyme A and carnitine distribution in normal and ischemic hearts.

  title={Coenzyme A and carnitine distribution in normal and ischemic hearts.},
  author={J A Idell-Wenger and Lee W. Grotyohann and Julian Neely},
  journal={The Journal of biological chemistry},
  volume={253 12},
The distribution of coenzyme A and carnitine between the mitochondrial and cytosolic compartments was determined in rat heart ventricular muscle. The CoA and carnitine levels of homogenate, mitochondrial, and postmitochondrial fractions were determined in nonperfused hearts and in hearts that were perfused under control and ischemic conditions. Using the mitochondrial marker enzymes, citrate synthase and cytochrome c oxidase, the cellular content of mitochondrial protein was determined to be 53… CONTINUE READING


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