Coeliac disease and autoimmune disease—genetic overlap and screening

@article{Lundin2015CoeliacDA,
  title={Coeliac disease and autoimmune disease—genetic overlap and screening},
  author={Knut E. A. Lundin and Cisca Wijmenga},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  year={2015},
  volume={12},
  pages={507-515}
}
  • K. Lundin, C. Wijmenga
  • Published 1 September 2015
  • Medicine, Biology
  • Nature Reviews Gastroenterology &Hepatology
Coeliac disease is a treatable, gluten-induced disease that often occurs concurrently with other autoimmune diseases. In genetic studies since 2007, a partial genetic overlap between these diseases has been revealed and further insights into the pathophysiology of coeliac disease and autoimmunity have been gained. However, genetic screening is not sensitive and specific enough to accurately predict disease development. The current method to diagnose individuals with coeliac disease is… 
View on Nature
ncbi.nlm.nih.gov
100 Citations
Highly Influential Citations
2
Background Citations
38
Methods Citations
1
Results Citations
1

100 Citations

Diagnosing coeliac disease: A literature review.
Searching for Celiac Disease Screening-detected celiac disease in an HLA-genotyped birth cohort
TLDR
HLA-genotyping could be used to select large populations to be screened for celiac disease and have systemically elevated pro-inflammatory cytokines and low BMD but normal values on a gluten-free diet, indicating that children with screening-detected Celiac disease could benefit from early identification and treatment.
Risk Factors Associated with the Occurrence of Autoimmune Diseases in Adult Coeliac Patients
TLDR
CD patients with family history of AD, overweight at CD diagnosis, and a delay of CD diagnosis had an increased risk of having another AD, and the benefit of CD screening in these specific subsets of patients with AD awaits further investigation.
Celiac disease: a comprehensive current review
TLDR
The present review is timely and provides a thorough appraisal of various aspects characterizing celiac disease, and the identification of alternative or complementary treatments to the gluten-free diet brings hope for patients unavoidably burdened by diet restrictions.
Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies
Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it…
SERONEGATIVE CELIAC DISEASE IN BRAZILIAN PATIENTS: A SERIES OF CASES.
TLDR
Patients who demonstrate the clinical profile of celiac disease with negative serology and normal levels of IgA, especially those who have family members with celiac Disease should be submitted to duodenal biopsies to look for histological findings.
Management of celiac disease in daily clinical practice.
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
TLDR
How myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling is discussed, and contribution of each of these factors to pathogenesis is discussed to enhance the view of this complex disorder and to contribute to a wider understanding of chronic immune-mediated disease.
Neuropsychiatric manifestations in celiac disease
Celiac disease susceptibility: The genome and beyond.
...
...

References

SHOWING 1-10 OF 138 REFERENCES
Coeliac Disease, autoimmune diseases and gluten exposure
TLDR
Despite that fact that patients with coeliac disease are at increased risk of various autoimmune conditions, the duration of gluten exposure seems not to be of crucial importance in the development of autoimmune diseases.
Coeliac disease: is it time for mass screening?
Gluten-free diet and autoimmune thyroiditis in patients with celiac disease. A prospective controlled study
TLDR
A gluten-free diet seemed not to prevent the progression of autoimmune process during a follow-up of 1 year, but Celiac patients had an increased risk of thyroid autoimmune disorders.
Autoimmune liver disease associated with celiac disease in childhood: a multicenter study.
Celiac Disease and Endocrine Autoimmunity
TLDR
The close relationship between CD and endocrine autoimmunity warrants a broader immune genetic and end hormone screening of CD patients and their relatives.
Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet.
  • J. CosnesC. Cellier I. Nion‐Larmurier
  • Medicine, Biology
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2008
Duration of gluten exposure in adult coeliac disease does not correlate with the risk for autoimmune disorders
TLDR
The prevalence of autoimmune diseases in patients with a late coeliac disease diagnosis does not correlate with duration of gluten intake and “actual gluten exposure” which takes into account diet compliance, follow up, and age at diagnosis of autoimmune disorders were not predictive for the risk of developing autoimmune diseases.
Coeliac disease
TLDR
Treatment is with a gluten-free diet, which constitutes a major challenge for some people, and most patients (but not all) can eat pure oats.
Prevalence of Celiac disease among children in Finland.
TLDR
The presence of serum tissue transglutaminase and endomysial autoantibodies is predictive of small-bowel abnormalities indicative of celiac disease and there is a good correlation betweenAutoantibody positivity and specific HLA haplotypes.
Autoantibodies in celiac disease
TLDR
The presence of anti-TG2 and other autoantibodies in celiac disease are examined, discussing their diagnostic value, their potential role in disease pathogenesis and current hypotheses that explain how their release may be triggered.
...
...