Coeliac disease

  title={Coeliac disease},
  author={Katri Lindfors and Carolina Ciacci and Kalle Kurppa and Knut E. A. Lundin and Govind Kumar Makharia and Mar{\'i}a Luisa Mearin and Joseph A. Murray and Elena F. Verdu and Katri Kaukinen},
  journal={Nature Reviews Disease Primers},
Coeliac disease is an immune-mediated enteropathy against dietary gluten present in wheat, rye and barley and is one of the most common lifelong food-related disorders worldwide. Coeliac disease is also considered to be a systemic disorder characterized by a variable combination of gluten-related signs and symptoms and disease-specific antibodies in addition to enteropathy. The ingestion of gluten leads to the generation of harmful gluten peptides, which, in predisposed individuals, can induce… 
Investigating coeliac disease patient transglutaminase 2-specific B cells in the duodenal bulb
The results suggest that a low number of TG2-specific B cells may develop at extra-follicular sites in the duodenal bulb mucosa.
Gluten gabeko dieta: Euskal Autonomia Erkidegoko pertsona zeliakoen dieta ohiturak
The aim of the present study was to assess the diet quality of children and adolescents with CD in order to attain optimal nutritional status, determining the most relevant factors that affect a balanced diet.


Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease
Findings reveal a state of systemic immune activation in conjunction with a compromised intestinal epithelium affecting a subset of individuals who experience sensitivity to wheat in the absence of coeliac disease.
The Molecular Basis for Oat Intolerance in Patients with Celiac Disease
It is concluded that some celiac disease patients have avenin-reactive mucosal T-cells that can cause mucosal inflammation and may be a reason for villous atrophy and inflammation in patients with Celiac disease who are eating oats but otherwise are adhering to a strict gluten-free diet.
Celiac disease: Autoimmunity in response to food antigen.
Current concepts of the immune pathology of CD are summarized with particular focus on recent advances in the understanding of disease specific B-cell responses.
Practical insights into gluten-free diets
awareness of the challenges, management and follow-up of patients with coeliac disease is increased to help them achieve GFD adherence and prevent complications whilst preserving their quality of life.
Living with coeliac disease and a gluten-free diet: a Canadian perspective.
  • M. Zarkadas, S. Dubois, +6 authors O. Pulido
  • Medicine
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
  • 2013
The present study quantifies the difficulties experienced, the strategies used and the emotional impact of following a gluten-free diet among Canadians with coeliac disease and highlights the need to improve the training and education of dietitians, other health providers and the food service industry workers.
A Non-Human Primate Model for Gluten Sensitivity
When fed with a gluten-containing diet, gluten-sensitive macaques showed signs and symptoms of celiac disease including chronic diarrhea, malabsorptive steatorrhea, intestinal lesions and anti-gliadin antibodies.
Identification of tissue transglutaminase as the autoantigen of celiac disease
Tissue transglutaminase is identified as the unknown endomysial autoantigen of celiac disease, and gliadin is a preferred substrate for this enzyme, giving rise to novel antigenic epitopes.
Duodenal-Mucosal Bacteria Associated with Celiac Disease in Children
The findings indicated that the disease is associated with the overgrowth of possible pathobionts that exclude symbionts or commensals that are characteristic of the healthy small intestinal microbiota.
Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet
Based on the results, good response to GFD sustained in long-term follow-up, but not all patients reach the level of healthy individuals.
Clinical benefit of gluten-free diet in screen-detected older celiac disease patients
A high index of suspicion and active case-finding in celiac disease is encouraged as an alternative to mass screening in older patients and screened patients benefited from a gluten-free diet.