• Corpus ID: 74037486

Coeliac disease – a retrospective and prospective view

  title={Coeliac disease – a retrospective and prospective view},
  author={Irena Barbari{\'c}},
Coeliac disease or gluten entheropathy is the lifelong gluten intolerance. Gluten is a protein contained within some cereals (wheat, rye and barley). In some areas of the world coeliac disease affects about 1% of general population. The rate of patients recognized with celiac disease depends mostly on novel diagnostic serologic tests but also on the awareness of health care providers that unspecific and very different signs and symptoms can indicate the diagnosis of this disease. In genetically… 

Tables from this paper



Celiac disease

Diagnosis requires endoscopy with jejunal biopsy and tissue-transglutaminase antibodies are important to confirm the diagnosis since there are other diseases which can mimic celiac disease.

Refractory celiac disease and sprue-like intestinal disease.

  • H. Freeman
  • Medicine
    World journal of gastroenterology
  • 2008
Celiac disease is a gluten-dependent small intestinal mucosal disorder that causes malabsorption, often with diarrhea and weight loss and some, but not all, may develop lymphoma.

Oats to children with newly diagnosed coeliac disease: a randomised double blind study

The addition of moderate amounts of oats to a GFD does not prevent clinical or small bowel mucosal healing, or humoral immunological downregulation in coeliac children, and indicates that oats, added to the otherwise GFD, can be accepted and tolerated by the majority of children with CD.

Diagnosis of coeliac disease: time for a change?

The Italian Working Group for Paediatric Gastroenterology undertook an evaluation of the current approach to the diagnosis of coeliac disease in Italy to verify whether a simplified, more flexible approach was possible.

Do you still need a biopsy to diagnose celiac disease?

The enzyme-linked immunosorbent assay (ELISA), which measures the antibodies directed against the autoantigen responsible for the disease (tissue transglutaminase), has also been developed and tested as a screening tool, but the poor positive predictive value of this test does not allow practitioners to diagnose celiac disease without the duodenal biopsy showing the typical morphologic changes.

The toxicity of high molecular weight glutenin subunits of wheat to patients with coeliac disease

Mixed HMW-GS stimulate T-cell lines from some coeliac patients and exacerbate coeliasis disease in vivo, inducing expression, within 2 h, of IL-15, which suggests an innate immune response to these proteins.

Effect of an oats‐containing gluten‐free diet on symptoms and quality of life in coeliac disease. A randomized study

The oats‐containing gluten‐free diet caused more intestinal symptoms than the traditional diet, and coeliac patients should be aware of the possible increase in intestinal symptoms.

Structural Basis for Gluten Intolerance in Celiac Sprue

A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to gluten in Celiac Sprue patients, and could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for CeliacSprue.

Undiagnosed coeliac disease at age seven: population based prospective birth cohort study

The prevalence of undiagnosed coeliac disease in the general population at age seven is established, and the associated clinical features are looked for.