Coeliac disease—a meeting point for genetics, immunology, and protein chemistry

  title={Coeliac disease—a meeting point for genetics, immunology, and protein chemistry},
  author={A. Mowat},
  journal={The Lancet},
  • A. Mowat
  • Published 2003
  • Biology, Medicine
  • The Lancet
  • CONTEXT Coeliac disease is caused by a genetically determined, specific immune response to antigens present in wheat gluten. This immune response may be focused on a limited region of the alpha gliadin component of gluten, and previous studies have suggested that the generation of epitopes for recognition by CD4+ T cells requires deamidation of the protein by tissue transglutaminase. However, it had not previously been shown that candidate epitope peptides could be generated from gluten in vivo… CONTINUE READING
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