Coeliac disease: genetic, immunological and environmental factors in disease pathogenesis.

@article{Kagnoff1985CoeliacDG,
  title={Coeliac disease: genetic, immunological and environmental factors in disease pathogenesis.},
  author={Martin F. Kagnoff},
  journal={Scandinavian journal of gastroenterology. Supplement},
  year={1985},
  volume={114},
  pages={45-54}
}
Coeliac disease in humans is activated by the dietary ingestion of wheat gliadins and similar proteins in other grains. We have studied genetic, immunological and environmental factors that may play a role in the pathogenesis of disease. In mice, two genetic regions, the major histocompatibility complex (H-2) and the immunoglobulin heavy chain constant region, were shown to regulate the production of anti-gliadin antibody. In coeliac disease patients on a gluten-free diet, elevated levels of… CONTINUE READING

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