Codon volatility as an indicator of positive selection: data from eukaryotic genome comparisons.

@article{Friedman2005CodonVA,
  title={Codon volatility as an indicator of positive selection: data from eukaryotic genome comparisons.},
  author={Robert L Friedman and Austin L. Hughes},
  journal={Molecular biology and evolution},
  year={2005},
  volume={22 3},
  pages={542-6}
}
It has been suggested that codon volatility (the proportion of the point-mutation neighbors of a codon that encode different amino acids) can be used as an index of past positive selection. We compared codon volatility with patterns of synonymous and nonsynonymous nucleotide substitution in genome-wide comparisons of orthologous genes between three pairs of related genomes: (1) the protists Plasmodium falciparum and P. yoelii, (2) the fungi Saccharomyces cerevisiae and S. paradoxus, and (3) the… CONTINUE READING

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