Codon-usage variants in the polymorphic (GGN)n trinucleotide repeat of the human androgen receptor gene

  title={Codon-usage variants in the polymorphic (GGN)n trinucleotide repeat of the human androgen receptor gene},
  author={R. Lumbroso and L. Beitel and D. Vasiliou and M. Trifiro and L. Pinsky},
  journal={Human Genetics},
  • R. Lumbroso, L. Beitel, +2 authors L. Pinsky
  • Published 1997
  • Biology, Medicine
  • Human Genetics
  • Abstract The human androgen receptor gene (hAR) has a long, polymorphic trinucleotide (GGN; glycine)n repeat in the 3′ portion of its first exon, with n = 10–31. Owing to technical difficulties that have precluded routine sequencing of this region, it is widely unknown that N represents T, G or C, and that the usual sense codon sequence of the GGN tract is (GGT)3GGG(GGT)2(GGC)4–25. Furthermore, on 4 of 61 X chromosomes, we observed that the internal GGT sequence was present three or four times… CONTINUE READING
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