Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes

@article{Sharp1986CodonUI,
  title={Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes},
  author={Paul M. Sharp and T. M. Tuohy and K. R. Mosurski},
  journal={Nucleic acids research},
  year={1986},
  volume={14 13},
  pages={5125-43}
}
Codon usage data has been compiled for 110 yeast genes. Cluster analysis on relative synonymous codon usage revealed two distinct groups of genes. One group corresponds to highly expressed genes, and has much more extreme synonymous codon preference. The pattern of codon usage observed is consistent with that expected if a need to match abundant tRNAs, and intermediacy of tRNA-mRNA interaction energies are important selective constraints. Thus codon usage in the highly expressed group shows a… CONTINUE READING
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