Codon-substitution models for heterogeneous selection pressure at amino acid sites.

  title={Codon-substitution models for heterogeneous selection pressure at amino acid sites.},
  author={Ziheng Yang and R. Nielsen and N. Goldman and Alice Marie Pedersen},
  volume={155 1},
Comparison of relative fixation rates of synonymous (silent) and nonsynonymous (amino acid-altering) mutations provides a means for understanding the mechanisms of molecular sequence evolution. The nonsynonymous/synonymous rate ratio (omega = d(N)d(S)) is an important indicator of selective pressure at the protein level, with omega = 1 meaning neutral mutations, omega < 1 purifying selection, and omega > 1 diversifying positive selection. Amino acid sites in a protein are expected to be under… CONTINUE READING
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