Codon conservation in the influenza A virus genome defines RNA packaging signals

@inproceedings{Gog2007CodonCI,
  title={Codon conservation in the influenza A virus genome defines RNA packaging signals},
  author={Julia R. Gog and Emmanuel Dos Santos Afonso and Rosa Maria Dalton and India Leclercq and Laurence S. Tiley and Debra Elton and Johann C. von Kirchbach and Nadia Naffakh and Nicolas Escriou and Paul Digard},
  booktitle={Nucleic acids research},
  year={2007}
}
Genome segmentation facilitates reassortment and rapid evolution of influenza A virus. However, segmentation complicates particle assembly as virions must contain all eight vRNA species to be infectious. Specific packaging signals exist that extend into the coding regions of most if not all segments, but these RNA motifs are poorly defined. We measured codon variability in a large dataset of sequences to identify areas of low nucleotide sequence variation independent of amino acid conservation… CONTINUE READING

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