Codon and amino-acid specificities of a transfer RNA are both converted by a single post-transcriptional modification

@article{Muramatsu1988CodonAA,
  title={Codon and amino-acid specificities of a transfer RNA are both converted by a single post-transcriptional modification},
  author={T. Muramatsu and K. Nishikawa and F. Nemoto and Y. Kuchino and S. Nishimura and T. Miyazawa and S. Yokoyama},
  journal={Nature},
  year={1988},
  volume={336},
  pages={179-181}
}
An Escherichia coli isoleucine transfer RNA specific for the codon AUA (tRNA2Ile or tRNAminorIle (ref. 1) has a novel modified nucleo-side, lysidine (L; ref. 2) (Fig. la) in the first position of the anticodon (position 34), which is essential for the specific recognition of the codon AUA (ref. 1). We isolated the gene for tRNA2Ile (ileX) and found that the anticodon is CAT, which is characteristic of the methionine tRNA gene. Replacement of L(34) of tRNA2Ile molecule enzymatically with… Expand
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