Codon Bias and Mutability in HIV Sequences

  title={Codon Bias and Mutability in HIV Sequences},
  author={Christopher R. Stephens and Henri Waelbroeck},
  journal={Journal of Molecular Evolution},
A survey of the patterns of synonymous codon preference in the HIV env gene reveals a correlation between the codon bias and the mutability requirements of different regions of the protein. At hypervariable regions in gp120 one finds a greater proportion of codons that tend to mutate nonsynonymously, but to a target that is similar in hydrophobicity and volume. We argue that this strategy results from a compromise between the selective pressure placed on the virus by the induced immune response… CONTINUE READING

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