Coding sequence-dependent ribosomal arrest at termination of translation

@article{Cao1996CodingSR,
  title={Coding sequence-dependent ribosomal arrest at termination of translation},
  author={J. Cao and A. Geballe},
  journal={Molecular and Cellular Biology},
  year={1996},
  volume={16},
  pages={603 - 608}
}
A remarkably high percentage of proto-oncogene, growth factor, cellular receptor, and viral transcript leaders contain short upstream open reading frames (uORFs), yet the significance and regulatory effects of these uORFs have not been well characterized. In the case of the human cytomegalovirus gpUL4 (gp48) transcript, the second of three uORFs (uORF2) inhibits translation of the downstream cistron by a process that depends on the uORF2 amino acid coding information. To investigate the… Expand
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