Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice

Abstract

The climbing fiber input to Purkinje cells acts as a teaching signal by triggering a massive influx of dendritic calcium that marks the occurrence of instructive stimuli during cerebellar learning. Here, we challenge the view that these calcium spikes are all-or-none and only signal whether the instructive stimulus has occurred, without providing parametric… (More)
DOI: 10.7554/eLife.03663

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