Coding of Sweet, Bitter, and Umami Tastes Different Receptor Cells Sharing Similar Signaling Pathways

@article{Zhang2003CodingOS,
  title={Coding of Sweet, Bitter, and Umami Tastes Different Receptor Cells Sharing Similar Signaling Pathways},
  author={Yifeng Zhang and M. Hoon and J. Chandrashekar and K. L. Mueller and Boaz Cook and Di Wu and C. Zuker and N. Ryba},
  journal={Cell},
  year={2003},
  volume={112},
  pages={293-301}
}
Mammals can taste a wide repertoire of chemosensory stimuli. Two unrelated families of receptors (T1Rs and T2Rs) mediate responses to sweet, amino acids, and bitter compounds. Here, we demonstrate that knockouts of TRPM5, a taste TRP ion channel, or PLCbeta2, a phospholipase C selectively expressed in taste tissue, abolish sweet, amino acid, and bitter taste reception, but do not impact sour or salty tastes. Therefore, despite relying on different receptors, sweet, amino acid, and bitter… Expand
Breadth of Tuning and Taste Coding in Mammalian Taste Buds
Taste perception and coding in the periphery
  • M. Sugita
  • Chemistry, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • 2006
Evidence for two populations of bitter responsive taste cells in mice.
The Receptors for Mammalian Sweet and Umami Taste
Elucidation of mammalian bitter taste.
  • W. Meyerhof
  • Medicine, Biology
  • Reviews of physiology, biochemistry and pharmacology
  • 2005
Signal transduction and information processing in mammalian taste buds
  • S. Roper
  • Biology, Medicine
  • Pflügers Archiv - European Journal of Physiology
  • 2007
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 70 REFERENCES
A Plethora of Taste Receptors
Molecular Mechanisms of Bitter and Sweet Taste Transduction*
  • R. Margolskee
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 2002
A family of candidate taste receptors in human and mouse
Transduction of bitter and sweet taste by gustducin
Individual mouse taste cells respond to multiple chemical stimuli
T2Rs Function as Bitter Taste Receptors
An amino-acid taste receptor
A cyclic–nucleotide–suppressible conductance activated by transducin in taste cells
A Novel Family of Mammalian Taste Receptors
Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells
...
1
2
3
4
5
...