Coding of Sweet, Bitter, and Umami Tastes Different Receptor Cells Sharing Similar Signaling Pathways

@article{Zhang2003CodingOS,
  title={Coding of Sweet, Bitter, and Umami Tastes Different Receptor Cells Sharing Similar Signaling Pathways},
  author={Yifeng Zhang and Mark A. Hoon and Jayaram Chandrashekar and Ken L. Mueller and Boaz Cook and Di Wu and Charles S. Zuker and Nicholas J. P. Ryba},
  journal={Cell},
  year={2003},
  volume={112},
  pages={293-301}
}

Figures from this paper

Review Taste perception and coding in the periphery
TLDR
In this view, the recent characterization of the cellular mecha- nisms underlying taste reception and perception, and of taste coding in the periphery will be discussed.
Breadth of Tuning and Taste Coding in Mammalian Taste Buds
TLDR
These data further elaborate functional differences between receptor cells and presynaptic cells, provide strong evidence for communication within the taste bud, and resolve the paradox of broad taste cell tuning despite mutually exclusive receptor expression.
Taste perception and coding in the periphery
  • M. Sugita
  • Biology
    Cellular and Molecular Life Sciences CMLS
  • 2006
TLDR
The recent characterization of the cellular mechanisms underlying taste reception and perception, and of taste coding in the periphery will be discussed.
Evidence for two populations of bitter responsive taste cells in mice.
TLDR
Analysis of dual responsive cells found that bitter responses were inhibited by the PLC inhibitor U73122, and Immunocytochemical analysis detected PLCbeta3 and IP(3)R1, indicating the presence of multiple PLC signaling pathways in taste cells.
The Receptors for Mammalian Sweet and Umami Taste
Elucidation of mammalian bitter taste.
  • W. Meyerhof
  • Biology
    Reviews of physiology, biochemistry and pharmacology
  • 2005
TLDR
Transgenic expression of a human TAS2R in sweet or bitter taste receptor-expressing cells of mice induced either strong attraction or aversion to the receptor's cognate bitter tastant, suggesting dedicated taste receptor cells appear to function as broadly tuned detectors for bitter substances and are wired to elicit aversive behavior.
The receptors and coding logic for bitter taste
TLDR
It is demonstrated, using a combination of genetic, behavioural and physiological studies, that T2R receptors are necessary and sufficient for the detection and perception of bitter compounds, and that differences in T2Rs between species can determine the selectivity of bitter taste responses.
Signal transduction and information processing in mammalian taste buds
  • S. Roper
  • Biology
    Pflügers Archiv - European Journal of Physiology
  • 2007
TLDR
It is now recognized that the cells responding to sweet, bitter, and umami taste stimuli do not possess synapses and instead secrete the neurotransmitter ATP via a novel mechanism not involving conventional vesicular exocytosis, which suggests that there is important information processing and signal coding taking place in the mammalian taste bud after gustatory stimulation.
Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation
TLDR
A comprehensive understanding is stimulated of how sweet compounds signal to the brain upon taste bud cells activation, and how this gustatory process is integrated with gastro-intestinal sugar sensing to create a hedonic and metabolic representation of sugars, which finally drives the authors' behavior.
...
...

References

SHOWING 1-10 OF 70 REFERENCES
A Plethora of Taste Receptors
Molecular Mechanisms of Bitter and Sweet Taste Transduction*
TLDR
The focus of this review is on recent advances in understanding of the transduction elements and signaling mechanisms underlying bitter and sweet taste transduction.
A family of candidate taste receptors in human and mouse
TLDR
The identification of a family of candidate taste receptors (the TRBs) that are members of the G-protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells are reported.
Transduction of bitter and sweet taste by gustducin
TLDR
Gustducin is a principal mediator of both bitter and sweet signal transduction, and its role in taste transduction is investigated by generating and characterizing mice deficient in the gustducin α-subunit.
Individual mouse taste cells respond to multiple chemical stimuli
TLDR
There appears to be no strict and separate detection of taste qualities by distinct subpopulations of taste cells in peripheral gustatory sensory organs in mice.
T2Rs Function as Bitter Taste Receptors
An amino-acid taste receptor
TLDR
This work identifies and characterize a mammalian amino-acid taste receptor and shows that sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses.
A cyclic–nucleotide–suppressible conductance activated by transducin in taste cells
TLDR
It is proposed that transducin, via phosphodiesterase, decreases cyclic nucleotide levels to activate the cyclic-nucleotide-suppressible conductance, leading to Ca2+ influx and taste-cell depolarization.
A Novel Family of Mammalian Taste Receptors
Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells
TLDR
It is suggested that rod transducin tranduces bitter taste by coupling taste receptor(s) to taste-cell phosphodiesterase through the recently identified cyclic-nucleotide-suppressible conductance.
...
...