Coding coenzyme handles: a hypothesis for the origin of the genetic code.

  • Eörs Szathmáry
  • Published 1993 in
    Proceedings of the National Academy of Sciences…


The coding coenzyme handle hypothesis suggests that useful coding preceded translation. Early adapters, the ancestors of present-day anticodons, were charged with amino acids acting as coenzymes of ribozymes in a metabolically complex RNA world. The ancestral aminoacyl-adapter synthetases could have been similar to present-day self-splicing tRNA introns. A… (More)


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