Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population.

@article{Mori2007CodingAN,
  title={Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population.},
  author={Keisuke Mori and Peter Gehlbach and Sho Kabasawa and Izumi Kawasaki and Masataka Oosaki and Hiroyuki Iizuka and Shigehiro Katayama and Takuya Awata and Shin Yoneya},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 11},
  pages={5315-9}
}
PURPOSE Ethnic variation has been reported in age-related macular degeneration (AMD)-associated Y402H polymorphism in complement factor H (CFH). This variation is evident in the Japanese population. Recently a strong association between a novel single-nucleotide polymorphism (SNP; rs1410996) in the CFH gene and AMD has been identified in Caucasian patients. The present study was undertaken to investigate whether four coding and noncoding variants of the CFH gene, including rs1410996, are… CONTINUE READING