Codetection of a mixed population of candHPV62 containing wild-type and disrupted E1 open-reading frame in a 45-year-old woman with normal cytology.

@article{Fu2004CodetectionOA,
  title={Codetection of a mixed population of candHPV62 containing wild-type and disrupted E1 open-reading frame in a 45-year-old woman with normal cytology.},
  author={Leiping Fu and Masanori Terai and Toshihiko Matsukura and Rolando Herrero and Robert D Burk},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={190 7},
  pages={1303-9}
}
We have cloned, sequenced, and characterized the complete genome of a novel human papillomavirus (HPV), candHPV62. During cloning, 2 candHPV62 viral isolates were recovered from a single cervical sample; 1 had all anticipated HPV open-reading frames (ORFs) intact, whereas the other exhibited an E1 frame-shift mutation. Further experiments indicated that the 2 strains were equivalent in abundance. It appears that an early mutation occurred within the E1 ORF, which was transcomplemented by an… CONTINUE READING

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