Codendrimer from polyamidoamine (PAMAM) and oligoethylene dendron as a thermosensitive drug carrier.

@article{Guo2014CodendrimerFP,
  title={Codendrimer from polyamidoamine (PAMAM) and oligoethylene dendron as a thermosensitive drug carrier.},
  author={Yifei Guo and Yanna Zhao and Jing Zhao and Xiangtao Wang and Afang Zhang},
  journal={Bioconjugate chemistry},
  year={2014},
  volume={25 1},
  pages={
          24-31
        }
}
The efficient synthesis of codendrimer PAMAM-co-OEG (PAG) and its properties in aqueous solution, including particle size and thermosensitivity, are described. PAG is synthesized with well-defined structure through the "attach to" route. In the aqueous solutions, PAG forms unimer and multimolecular aggregates with the respective particle sizes of approximately 8 and 200 nm, depending on the concentration. PAG shows thermosensitive behavior with sharp and fast transition, and the lower critical… CONTINUE READING
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