Codelivery of the chemokine CCL3 by an adenovirus-based vaccine improves protection from retrovirus infection.

@article{Lietz2012CodeliveryOT,
  title={Codelivery of the chemokine CCL3 by an adenovirus-based vaccine improves protection from retrovirus infection.},
  author={Ruth Lietz and Wibke Bayer and Teona Ontikatze and Lena Johrden and Matthias Tenbusch and Michael Storcksdieck genannt Bonsmann and Klaus Uberla and Ulf Dittmer and Oliver Wildner},
  journal={Journal of virology},
  year={2012},
  volume={86 3},
  pages={
          1706-16
        }
}
Processing and presentation of vaccine antigens by professional antigen-presenting cells (APCs) is of great importance for the efficient induction of protective immunity. We analyzed whether the efficacy of an adenovirus-based retroviral vaccine can be enhanced by coadministration of adenovirus-encoded chemokines that attract and stimulate APCs. In the Friend retrovirus (FV) mouse model we coexpressed CCL3, CCL20, CCL21, or CXCL14 from adenoviral vectors, together with FV Gag and Env antigens… CONTINUE READING

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