CodY deletion enhances in vivo virulence of community-associated methicillin-resistant Staphylococcus aureus clone USA300.

@article{Montgomery2012CodYDE,
  title={CodY deletion enhances in vivo virulence of community-associated methicillin-resistant Staphylococcus aureus clone USA300.},
  author={Christopher P. Montgomery and Susan Boyle-Vavra and Agn{\`e}s Roux and Kazumi Ebine and Abraham L. Sonenshein and Robert S. Daum},
  journal={Infection and immunity},
  year={2012},
  volume={80 7},
  pages={2382-9}
}
The Staphylococcus aureus global regulator CodY responds to nutrient availability by controlling the expression of target genes. In vitro, CodY represses the transcription of virulence genes, but it is not known if CodY also represses virulence in vivo. The dominant community-associated methicillin-resistant S. aureus (CA-MRSA) clone, USA300, is hypervirulent and has increased transcription of global regulators and virulence genes; these features are reminiscent of a strain defective in CodY… CONTINUE READING
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Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus

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